Fusogenic lipid

Fucosyltransferase 355 3-Fucosyltransferase 925 Fusigenic-hemagglutinating-virus 307 Fusogenic lipids 1523... 

Liposomes. Liposomes are vesicles that consist of an aqueous compartment enclosed in a phospholipids bilayer. As they lack proteinaceous components, liposomes are not immunogenic. A broad variety of cationic liposomes containing eventually modified lipids have been used to deliver pDNA and mRNA for therapeutic utilizations. These formulations are usually based on a cationic lipid such as l,2-dioleol-3-trimethylammonium propane (DOTAP) and a fusogenic lipid such as l,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) [22,23]. Despite their ease of production and efficacy in vitro for transfecting cultured cells, cationic liposomes face toxicity issues in vivo [24,25]. Meanwhile, their heterogeneous size... 

Fusogenic lipids. Mixed monolayers of fusogenic lipids with dpPC showed ion-dipole interactions with decreases in the surface potential that occurred together with negative deviations in the area occupied per molecule, with respect to ideal films. 

When Ca (or UO ) was present in the subphase (Fig. 3), a mixed monolayer of GMO with dpPE also showed negative deviations in the molecular area and surface potential and behaved, at high pressures, like a mixed monolayer with dpPC. Such experiments indicated that dpPE can show interactions with fusogenic lipids similar to dpPC, depending on the surface pressure of the film and on the degree to which the dipolar properties are constrained by the influence of an external bivalent metal ion (Maggio Lucy, 1976). 

The effects described here in a model membrane may have some implications for membrane fusion. When a fusogenic lipid is introduced into the asymmetric bilayer structure of an erythrocyte membrane (Zwaal et al., 1973) it may initially interact with choline-containing phospholipids in the outer half of the bilayer (Maggio Lucy, 1975). This will alter the phospholipid head groups and... 

Fusogenic lipids interact with phosphatidylcholine at the air-water interface showing reductions in the surface potential and area per molecule. These effects may reflect an arrangement of phospholipid dipoles that allows a closer packing in the monolayer. 

Interactions of membrane phospholipids with fusogenic lipids, Biochim. Biophys. Acta 332 1-10 (1973). 

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