Fused genes

Fused gene or gene pair analysis to estimate domain interaction Selection pressure promotes retention of gene fusion in ensuring protein domain interactions over the course of evolution. Symmetry and sequence clustering of gene sequences to detect fusion genes Functional associations of proteins [21,20]... 

Huber M, Siegenthaler G, Mirancea N, Marenholz I, Nizetic D, Breitkreutz D, Mischke D, Hohl D. 2005. Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex. J Invest Dermatol 124(5) 998-1007. 

Fused genes are used to transform bacterial cells... 

Shtivelman, E. Lifshitz, B. Gale, R.P. Roe, B.A. Canaani, E. Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. Cell, 47, 277-284 (1986)... 

Recombinant DNA technology not only allows researchers the ability to manipulate individual genes but to fuse genes encoding individual proteins together to develop chimeric or fusion proteins. These fusion proteins may have the fimction of one of the proteins, exhibit properties of both proteins, or acquire a new fimction altogether. The ELP sequence derived from elastin has been used... 

The enormous task of determining the function and cooperation of proteins to create and maintain biological systems draws on various methods, e.g., patterns of co-occurrence identified from fused genes. 

Efficiency is achieved by a combination of experiments and computation, i.e. merging the results of expression profiling with DNA micro arrays with computation (co-occurrence, phylogenetic profiles and fused genes). 

Hernandez, L, Pinyol, M., Hernandez, S. et fli. (1999) TRK-fused gene (TEG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally differentTFG-ALKtranslocations. Blood, 94, 3265-3268. 

Primordial Fused Genes Become Oncogenes and Encode Oncoproteins... 

Primordial Fused Genes Roll Evolution Forward... 

Comment. In the oomycete, the protein products of the fused genes are chemotherapy-resistant, similarly to fused oncogene-product oncoproteins of malignantly transformed stem- or somatic cells of the higher multicellular hosts. Figure 56 and Table XXX (yide infra) refer to the similarities of Phytophthora infestans in action to malignantly transformed higher eukaryotes. 

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