Furin

G. Furin, in L. German and S. Zemskov, eds., New EluonnatingA.gents in Organic Synthesis, Springer-Vedag, Berlin, 1989, Chapt. 9, p. 35. 

Kinetics of Nucleophilic Substitution Reactions of Polyfluoroaromatic Compounds Rodionov, P P, Furin, G G J Fluorine Chem 47. 361 34 105 ... 

The anthrax toxin is a tripartite toxin and consists ofthe binding component protective antigen (PA), the lethal factor (LF), which is a metalloprotease, and the edema factor (EF), which is a calmodulin-dependent adenylyl-cyclase. Both enzyme components are translocated via PA into target cells. PA is activated by furin-induced cleavage and forms heptamers, which are similar to the binding components of C2 toxin and iota toxin. In the low pH compartment of endosomes, the heptamers form pores to allow translocation of LF and EF. LF cleaves six of the seven MEKs (MAPK-kinases) thereby inhibiting these enzymes. The functional consequence is the blockade of the MAPK pathways that control cell proliferation, differentiation, inflammation, stress response, and survival. Whether this is the reason for the LT-induced cell death of macrophages is not clear [1]. 

Furin, also known as paired basic amino-acid-cleaving enzyme (PACE), is a membrane bound subtilisin-like serine protease of the irons Golgi compartment. It is ubiquitously expressed and mediates processing of many protein precursors at Arg-X-Lys/Arg-Arg sites. 

So far, seven mammalian precursor convertases (PCs) have been identified furin, PCI, PC2, PC4, PC5, PACE4 and PC7. 

A furin-like protease is a recursor (prehormone, preprotein) conveitase (PC). 

Fungicidal Effect Fungistasis Funicular Myelitis Furin... 

For a review of SbCl5 as a Friedel-Crafts catalyst, see Yakobson, G.G. Furin, G.G. Synthesis, 1980, 345. 

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