Funtumia elastica

Hevea species. Ficus elastica, Landolphia species, Castilloa elastica, Hancornia speciosa, Forsteronia species, Funtumia elastica and F. africana, Manihot species, Clitandra species and various species of Euphorbia furnish most of the Rubber of commerce. 

Irehamine was isolated (39) from the leaves of Funtumia elastica (Preuss.) Stapf. The structure LIII of this alkaloid follows from its preparation from 20a-amino-3/3-hydroxypregn-5-ene via the X-carb-ethoxy derivative LII and reduction of the latter with lithium aluminum hydride. In accord with this structure irehamine was converted to funtuphyllamine-B XXVII on catalytic hydrogenation (39). 

This alkaloid was isolated from the leaves of Funtumia elastica its formation by Eschweiler-Clarke methylation of 20a-aminopregn-5-en-3/3-ol provided proof of its structiu e (LIV) which was further confirmed (39) by the result of the catalytic hydrogenation of irehine leading to funtuphyllamine-C (XXVIII). 

This alkaloid (LXXI) was isolated from the leaves of Funtumia elastica (63). The NMR-spectrum disclosed the presence of two primary amino groups, one olefinic proton (multiplet at 4.7 t), one secondary, and two tertiary methyl groups. On Ruschig deamination the alkaloid afforded progesterone and on methylation with formic acid-formaldehyde it yielded a tetramethyl derivative which proved to be identical with the known (64) 3j8,20a-bisdimethylaminopregn-5-ene. 

Monoamino-alkaloids have been isolated, in general, from the feebly basic fractions. It was in this way that Voticky and Tomko " isolated an amino-pregnane, irehine, from the leaves of B. sempervirens. Irehine was earlier extracted from the leaves of an Apocynacea, Funtumia elastica Other alkaloids isolated from different Buxus species are derivatives of methyl-pregnanes, and a few amongst them have been already described. ... 

The major alkaloids of the seed of Funtumia elastica are irehdiamines A, B, C, and D. Four minor alkaloids, i.e. conamine (Id), conessine (Ic), tetramethyl-horrhimine (15a), and a new base, 20-epi-irehdiamine I (15b), have now been isolated from seeds of this plant. The structure of the latter base was assigned on the basis of its n.m.r. and mass spectra, and confirmed by its synthesis from progesterone by an unexceptional route. ... 

Agyare C, Koffuor GA, Boakye YD, Mensah KB. Antimicrobial and antiinflammatory properties of Funtumia elastica. Pharm Biol 2013 51(4) 418-25. 

Apocynaceae Lagos silk rubber Funtumia elastica... 

A chemical analysis of the latex from Funtumia elastica gave the following results ... 

D. Spence t has investigated the effect of precipitating agents on the latex, Funtumia elastica, in the natural state. His results are in keeping with those of Henri except, of course, that the latter worked with the dialyzed latex. 

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