Fungal infection lymph nodes

Pneumogstis carini pneumonia (PCP), the most common of the opportunistic infections, occurs in more than 80% of AIDS patients (13). Toxoplasmosis, a proto2oan infection of the central nervous system, is activated in AIDS patients when the 004 count drops and severe impairment of ceU-mediated immunity occurs. Typically, patients have a mass lesion(s) in the brain. These mass lesions usually respond well to therapy and can disappear completely. Fungal infections, such as CTyptococcalmeningitis, are extremely common in AIDS patients, and Histop/asma capsulatum appears when ceU-mediated immunity has been destroyed by the HIV vims, leading to widespread infection of the lungs, Hver, spleen, lymph nodes, and bone marrow. AIDS patients are particularly susceptible to bacteremia caused by nontyphoidal strains of Salmonella. Bacteremia may be cleared by using antibiotic therapy. 

A variety of diseases affect the lymphatic system early in their time course. For example, many cancers spread by lymphatic dissemination, and HIV, fungal, and bacterial infections are located primarily in the lymph nodes. The high prevalence of lymph node involvement in disease is due to the role of lymphatic tissue in the provision of the body s immune response. Intralymphatic and interstitial administration are two efficient access routes. However, the oral route may also prove to be important for the lymphatic uptake of lipophilic drags and macromolecules. 

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