Fungal antitumor activity

Phenylahistin, a fungal DKP metabolite composed of Phe and isoprenylated dehydrohistidine exhibits potent in vitro and in vivo antitumor activity. ... 

Antitumor Activity of Some Fungal Glucans Against Subcutaneously Implanted Sarcoma 180 in Mice"... 

C21H35NO, Mr 317.51, yellow oil, [ajp + 22.0 (CHClj). Fungal amino alcohol from a Preussia sp., produced also by Aspergillus ochraceus. The substance class has antifungal activity and especially an-isomycin shows strong antitumor activity. 

Most fungal (3-glucans have been reported to have antitumor activity (Table 3.6). For example, schizophyllan has been used as immunotherapeutic agent in cancer treatment, in conjunction with chemo- and radiotherapy, in Asia for decades [106]. Lentinan has... 

Chitinous polymers of fungal origin have still not been extensively studied, but crustacean chitin and its derivatives (e.g., chitosan, carboxymethylchitin) are known to possess antitumor activity [196]. Nevertheless, fungal CGC has been reported to have enhanced anti cancer activity compared to chitin, probably because the copolymer combines the properties of (3-glucans and chitin polymers [8]. 

The fungal metabolite (+)-brefeldin A (325) displays potent antitumor, antifungal, antiviral, antimitotic, and immunosuppressive activities. Recently, Romo and Wang described a highly concise total synthesis of 325 by a combined /J-lactone-CM approach (Scheme 63), that again underlines the high tolerance of sensitive functionality exhibited by the second-generation Ru catalysts [ 145]. 

Wipf and co-workers developed a general route for the construction of the spiroketal naphthodecalines (155) using PIDA in CF3CH2OH and the first total syntheses of palmarumycin CPX (42) and ( )-deoxypreussomerin A (43), which are fungal metabolites showing antitumor and antibiotic activities [117, 118] (Scheme 27). 

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