Functions of the Tcfs in Mammalian Development

Expression of Tcf-3 and Tcf-4 differs markedly within the developing mouse embryo (Korinek et al., 1998a). In situ analysis revealed that Tcf-3 is 

Tcf/p-CATENIN COMPLEXES BIPARTITE TRANSCRIPTION FACTORS INVOLVED IN WINGLESS/Wnt SIGNALING 

In agreement with these Xenopus data, several studies have demonstrated a strong correlation between coexpression of Wnt-1 and the formation of transcriptionally active nuclear Tcf/p-catenin complexes in cell lines (Ko-rinek et al., 1998a Hsu et al., 1998). 

Transcriptional activation of target genes in response to Wingless/Wnt signaling is dependent on the nuclear translocation of free cytoplasmic p- 

Conductin was originally identified during a two-hybrid screen for proteins interacting with p-catenin (Behrens et al., 1998). It was subsequently shown to have additional binding sites for APC and GSK3p and to readily 

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