Development mouse embryo

Palis, J., et al. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse, Development, 126, 5073, 1999. 

Fig. 1. Dynamics of DNA methylation levels during mouse development. The methylation patterns of the oocyte and the rapidly demethylated after fertilization sperm create the combined methylation patterns in the early mouse zygote. During the first two to three cleavage divisions, the 5mC levels decrease further and stay low through the blastula stage. Post-implantation, the mouse embryo genome is methylated de novo the CpG islands remain mostly unmethylated. The primordial germ cells remain unmethylated. During gametogenesis specific parental (maternal or paternal) patterns of DNA methylation are established at imprinted loci (for further details see Refs. [13, 14]) (re-drawn from Ref [4]).

Mouse, Teratology, Developmental toxicity, Embryo-fetal development, Embryo-... 

The combined fertility and embryo-fetal development study is described as a two study design in the ICH S5(R2) guideline (1) and is anticipated for use in rodents (usually rat but also the mouse) embryo-fetal development must still be evaluated in a second, nonrodent, species. 

Singh AV et al (2007) Integrative database management for mouse development systems and concepts. Birth Defects Res C Embryo Today 81 1-19. doi 10.1002/bdrc.20089... 

The production of transgenic animals carrying rDNA in their genome arose from a combination of advances in embryology [239], understanding the differentiation of stem cells [240] in the developing embryo, and development of viral vectors [241]. This has had a broad range of applications, from production of knockout mice for fundamental research to animal models for human disease (e.g., a mouse model for HCV infections [242]). 

Basic development of mouse embryos has been more than adequately described in several landmark texts, such as The Mouse by Roberts Rugh (8), The House Mouse by Karl Theiler (9), The Atlas of Mouse Development by M.H. Kaufman (10), and Mouse Development by Janet Rossant and Patrick Tam (11) therefore, we did not consider it necessary for this to be duplicated in this text. The chapters in this section on the mouse as a developmental model provide the background... 

Sturm K, Tam PPL (1992) Isolation and culture of whole postimplantation embryos and their germ layer derivatives. In Wassarman P, DePamphilis M (eds) Methods in enzymology . guide to techniques in mouse development. Academic Press, New York, pp. 164-190. 

In situ hybridization revealed high levels of both class I and IV ADH messenger RNAs in adrenal glands of 16.5 day mouse embryos as wells as significant amounts of RA, suggesting this organ as a potential endocrine source of this hormone during mouse development [64]. 

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