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Signaling by Nuclear Receptors

The primary regulating factor for signal transduction via nuclear receptors is the hormone concentration. The amoimt of a hormone available for intracellular binding to the receptor is controlled by a number of processes  [Pg.148]

The biosynthesis and secretion of a hormone is regulated by a number of mechanisms and they themselves are involved in complex regulatory schemes. An informative example is the hierarchically ordered hypothalamus-hypophysis system which regulates the biosynthesis and secretion of many hormones of the nuclear receptors. [Pg.148]

Tabelle 4.1. Ligands and structure of HREs of selected nuclear receptors from mammals. [Pg.150]

Receptor Hormone Half site sequence configuration of HRE [Pg.150]

Thyroid hormone receptor, T3R 3,5,3 -L- triiodothyronine, T3 hormone RGGTCA IR-0, DR-4, ER-6,8 [Pg.150]

Signaling by nuclear receptors is regulated at various levels (Fig. 4.12). The following are important regulatory attack points ... [Pg.169]

See other pages where Signaling by Nuclear Receptors is mentioned: [Pg.148]    [Pg.150]    [Pg.152]    [Pg.153]    [Pg.153]    [Pg.154]    [Pg.156]    [Pg.158]    [Pg.160]    [Pg.162]    [Pg.164]    [Pg.166]    [Pg.167]    [Pg.168]    [Pg.170]    [Pg.172]    [Pg.124]    [Pg.151]    [Pg.152]    [Pg.153]    [Pg.154]    [Pg.156]    [Pg.158]    [Pg.160]    [Pg.162]    [Pg.164]    [Pg.166]    [Pg.168]    [Pg.169]    [Pg.169]    [Pg.170]    [Pg.172]    [Pg.174]    [Pg.176]   


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Nuclear receptors

Principles of Signaling by Nuclear Receptors

Regulation and Variability of Signaling by Nuclear Receptors

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