Functional groups inductive interactions

Systemization and analysis of literature data bearing on the quantitative estimation of inductive interaction of functional groups in organic and organometallic compounds... 

Site-specifically modified RNAs have been used in many applications to examine RNA stmcture-function relationships, RNA-protein interactions, RNA-ligand interactions, and RNA-catalysis mechanisms. Some earlier studies demonstrated the use of synthetic oligonucleotides to probe the roles of specific functional groups and detailed mechanisms in ribozyme catalysis (55). The synthesis of nucleoside analogs allows for a full-range of chemical diversity (e.g., inductive effects, space-filling capacity, etc.) to be explored, such that quantitative stmcture activity relationships can be determined for RNA enzymes and other biologically important RNAs (56). 

Fluorophihcity decreases in the presence of functional groups capable of intermolecular attractive interactions (through orientation forces, hydrogen bonds or induction forces). This effect can be counterbalanced by introducing more fluorous ponytails in the molecular structure. 

Finally this method can tell if two phases should give comparable performances or if a phase is better for an analyte with a specific functional group. Each of the test compounds yields particular information regarding the stationary phase benzene for the inductive effect, pyridine for proton accepting, butanol for hydrogen bonding, nitropropane for dipolar interactions... 

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