Functional groups chemical array fabrication

Abstract The immobilization of nucleic acids onto substrates in array fabrication is a complex process involving three major steps (i) the chemical modification of the arrayed material in such a fashion that it can interact with complementary functionalities present on the substrate to form a stable bond (ii) the coating of the support surface with adequate fimctional groups to allow specific binding and prevent nonspecific adsorption of the material to be arrayed and (iii) the use of a delivery system that brings small quantities of the arrayed material to specific positions on the surface. 

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