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Functional groups amino acid properties affected

Posttranslational modification (PTM) with functional groups is a universal mechanism for diversifying the activities of proteins. PTMs can affect many properties of proteins, such as localization, activity status, interaction networks, solubility, folding, turnover, or stabUity. It is therefore of vital importance to accurately determine the identities of modified proteins, the modified amino acid residues, and the covalently attached group. This chapter describes the process of PTM identification using the adenylylation (i.e., the covalent transfer of an adenosine monophosphate (AMP)) of rat sarcoma related in brain (Rab) proteins hy Legionella pneumophila enzymes as an example. It also deals with the development of PTM-specific antibodies from synthetic peptides. This account underlines the importance of chemical biology in the elucidation of PTMs. [Pg.141]

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Acidic function

Acidic functional groups

Acidic functionalities

Acidity functions

Affecting Amino Groups

Amino Functions

Amino acid functional groups

Amino acids function

Amino acids functional properties

Amino acids groupings

Amino functional groups

Amino functions, functional groups

Functional properties

Property group

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