Functional Group Transformations that Generate Amines

Functional Group Transformations that Generate Amines 

Even the most simple non-a-amino carboxylic acids are important compounds. The initial focus is on the co-aminoalkanoic acids (the amino group is on the carbon furthest removed from the carboxyl group), since they describe the types of amino acids to be discussed. Perhaps the simplest non-a-amino carboxylic acid is 2-amino propanoic acid, which has the common name of p-alanine (7.1). 4-Aminobutanoic acid (7.2) is also known as y-aminobutyric acid and given the abbreviation GABA. 

5-Aminopentanoic acid (7.5) is known as 8-aminovaleric acid and given the abbreviation DAVA. Both 6-aminohexanoic acid (7.4), also known as aminocaproic acid, and 7-aminoheptanoic acid (7.5) are well known. 8-Aminooctanoic acid (7.5), 

9-amino-nonanoic acid (1.7) and 10-aminodecanoic acid (1.8), which is also known as aminocapric acid, complete the first eight amino carboxylic acids in this series. 

This section will include functional group transformations that convert one group into an amine, using ammonia or an amine as a nucleophile. The fundamental idea behind this approach is to functionalize a halide (or another molecule bearing a suitable leaving group) by direct incorporation of an amino group. 

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Functional Group Transformations that Generate Amines... 

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