Functional age

Plowden, J. et al. (2004) Innate immunityin aging impact on macrophage function. Aging Cell, 3 (4), 161-167. 

Coverage confirmation, time to provide full foam coverage, leaks, blockages, rupture disk function, age of foam, portioning calibration mechanisms, performance of delivery pumps or bladder tanks, foam drain times, etc. should be verified for each unique system. NFPA 11 provides guidance in the specific test requirements for several characterisitic foam systems. 

The absolute value of the IgG concentration in CSF depends on the IgG concentration in serum, blood-brain barrier function, age of the patient, volume of CSF extracted, and local IgG synthesis in the central nervous system. Older studies used the IgG/TP ratio or IgG/albumin CSF ratio to estimate intrathecal production of IgG in CNS. To achieve a quantification of IgG intrathecal production, an empirical Tourtelotte s formula derived from three sources was proposed ... 

Early clinical studies are performed in cancer patients in hospitals instead of healthy volunteers, and in specialized Phase I units. Selection criteria for patients entered into cetuximab Phase I studies included various important factors such as disease state, life expectancy (>3 months), prior treatment, organ function, age, tumor type and target (i.e., EGFR expression). Therefore, pharmacokinetic (PK) data obtained from these individuals is confounded by numerous factors, a fact usually absent in conventional studies with tightly controlled, well-selected healthy subjects performed for non-oncologic drags. 

Figure 14, CO2 formed as a function ageing time of PECO-1 and PECO-2 (in duplicate) and PBT aged in borosilicate vessels filled with dry air a WOM,...

Aminoglycosides are almost exclusively eliminated by glomerular filtration. Elimination is dependent on cardiovascular and renal function, age, fever, other physiological factors and the V. The half-lives are usuaUy 1-2 h in normal adult horses but are increased in horses with renal dysfunction and in neonates. Increased dosage intervals must be used in these patients to prevent nephrotoxicity. The renal elimination of the aminoglycosides increases with age. The half-life of gentamicin is approximately 50% longer in 1-day-old than in 30-day-old foals. 

Costa PT, McCrae RR. Functional Age A Conceptual and Empirical Critique. Washington, DC U.S. Government Printing Office, 1977 23-32. 

Fig. 21.15 The threshold aging temperature as a function aging duration for the established criteria used to indicate Cu/CHA SCR failures [6]. Copyright SAE International. Reprinted with permission from 2009-01-1282...

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