Function of the Renal System

The primary function of the renal system is the elimination of waste products, derived either from endogenous metabolism or from the metabolism of xenobiotics. The latter function is discussed in detail in Chapter 10. The kidney also plays an important role in regulation of body homeostasis, regulating extracellular fluid volume, and electrolyte balance. 

A Textbook of Modern Toxicology, Third Edition, edited by Ernest Hodgson ISBN 0-471-26508-X Copyright 2004 John Wiley Sons, Inc. 

In animal studies of nephrotoxicity not only can histopathology be carried out but various biochemical parameters can be compared with those from untreated animals. They include lipid peroxidation and covalent binding to tissue macromolecules. 

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The renal system plays an important role in the regulation of fluids and electrolytes and is one of the two major systems involved in restoration of acid-base balance. In addition, the renal system has other vital roles, such as production of erythropoetin needed for red blood cells health, essential for oxygenation of tissues. The primary functions of the renal system are... 

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