Fruit polyphenols as neuroprotective agents

We have previously demonstrated that treatment of hippocampal cells with BB can prevent disruptions in Ca buffering capacity induced by exposure to oxidative and INF stressors (Joseph et al, 2007b). In addition, we have shown, thus far, that BB treatment was effective in protecting against amyloid beta (A 342)-induced or DA-induced 

The aforementioned studies have clearly demonstrated the efficacy of berry fruits and grapes in impacting cognitive and motor function. The putative mechanisms behind these improvements are diverse and could include direct antioxidant effects as well as actions on neuronal cell signaling cascades and INF processes. 

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