Friedel Crafts reaction environmentally friendly process

In addition, this acylating reaction turns out to be very "environmentally friendly" process compared to the classical Friedel-Crafts reaction catalyzed by aluminium chloride, generating only byproducts such as acidic acid which can easily be recovered and recycled. [Pg.37]

Iron salts have recently attracted considerable attention as inexpensive and environmentally friendly agents in a wide range of selective processes in organic synthesis. Over the past decade, FeCls 6H2O has shown to be an effective catalyst in the formation of carbon-carbon or carbon-nitrogen bonds, in intramolecular Friedel-Craft reactions and in the reduction of ketones or allylic alcohols. ... [Pg.143]

Typically, stoichiometric amounts of a Lewis acid such as AICI3 are required and produce stoichiometric amounts of salts and mineral acids (HX) as side products. Furthermore, undesired side reactions such as multiple alkylations and a low functional group tolerance are observed. With the need for more environmentally and economically benign processes, the development of Friedel-Crafts-type reactions using catalytic amounts of a Lewis acid catalyst is desirable. In addition, the substitution of benzyl halides for other environmentally friendly alkylating reagents constitutes an attractive goal. In particular, benzyl alcohols are suitable... [Pg.118]

In comparison with molecular catalysts, solid catalysts can be isolated from the reaction mixtures by filtration or used in continuous processes this is both environmentally friendly and useful in laboratory-scale experiments. The most important reactions catalyzed by solid superbases are isomerization reactions and the alkylation of substituted arenes in the side chain (Scheme 2). They proceed at room temperature or below with high yield (typically >99%). The surperbase-cata-lyzed alkylation of aromatic compounds complements the acid-type Friedel-Crafts alkylation and acylation, because the latter results in ring alkylation, whereas the former results in side-chain alkylation. [Pg.411]