Free radicals antioxidants and

Halliwell, B., Free radicals, antioxidants, and human disease curiosity, cause, or consequence Lancet, 344, 721,1994. 

Fang, Y.Z., Yang, S., Guoyao, W. (2002). Free radicals, antioxidant, and nutricion. Nutrition 18 872-9. 

Fang Y-Z, Yang S, Wu G. (2002) Free radicals, antioxidants and nutrition. Nutrition 18 872-879. 

Halliwell, B., Gutteridge, J.M., and Gross, C.E. Free radical antioxidants and human disease. Where are we now Journal of Laboratory and Clinical Medicine, 119, 598-620. 1992. 

Various carbonyl compounds and decomposition products of methyl linolenate hydroperoxides were tested for their interaction with DNA by measuring fluorescence in the presence of ferric chloride and ascorbic acid. 2,4-Alkadienals and 2,4,7-decatrienals were among the most active decomposition products of linolenate hydroperoxides (Table 5.8). To determine the type of reactive species involved in fluorescence formation with DNA, the effect of free radical antioxidants and a singlet oxygen quencher were examined. )3-Carotene, a-tocopherol and phenolic antioxidants strongly inhibited DNA fluorescence formed by decomposition of linolenate hydroperoxides in the presence of ferric chloride and ascorbic acid (Table 5.9). These results indicate that singlet oxygen and free radical species are important intermediates in the interaction of linolenate hydroperoxides with DNA in the presence of iron and ascorbic acid. 

Halhwell, B., Free Radicals, Antioxidants, and Human Disease Curiosity, Cause, or Consequence Lancet 1994 344 721-724. 

Lobo V, Patil A, Phatak A et al (2010) Free radicals, antioxidants and functional foods impact on human health. Pharmacogn Rev 4 118-126... 

In contrast, antioxidants can have an opposite effect when peroxide curing. Because peroxide cross-linking involves a free-radical mechanism, and antioxidants are designed to scavenge free radicals, it is obvious that peroxide efficiency can be compromised by the addition of antioxidants. Thus the decomposition products of the ppds were acting as accelerators (29). 

Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine, Vol.26, No.9-10, (May 1999), pp.l231-1237, ISSN 0891-5849. 

BROWN M s and goldstein j l (1990) Scavenging for receptors Nature 343, 508-9. ESTERBAUER H, GEBiKi J, PUHL H and JURGENS G (1992) The role of lipid peroxidation and antioxidants in oxidative modification of LDL Free Radical Biology and Medicine 13, 341-90. 

ROY s, SEN c K, KOBUCHi H and PACKER L (1998) Antioxidant regnlation of phorbol ester-indnced adhesion of hiunan Jurkat T-cells to endothehal cells Free Radical Biology and Medicine 25, 229—41. 

Beyer, R.F. (1990). The participation of coenzyme Q in free radical production and antioxidation. Free Rad. Biol. Med. 8, 545-565. 

Bolli, R., Jeroudi, M.O., Patel, B.S., Aruoma, O.I., Halliwell, B., Lai, E.K. and McCay, P.B. (1989). Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfiision. Circ. Res. 65, 607-622. 

Marubayashi, S., Dohi, K., Sumimoto, K., Oku, J., Ochi, K. and Kawasaki, T. (1989). Changes in activity of free radical scavengers and in levels of endogenous antioxidants during hepatic ischaemia and subsequent reperfusion. Transplant. Proc. 21, 1317-1318. 

Cellular and extracellular mechanisms that exist to limit the toxicity of free radicals (antioxidants) are known to be deficient in diabetes... 

The additional protection given to nylon by antioxidants has already been mentioned. Since the need is to protect against oxidation by free radicals, antioxidants are essentially of two types peroxide decomposers and radical scavengers. Reviews of these products are available [409,410,413] these should be consulted for details of the mechanisms involved. Peroxide decomposer types include compounds of manganese (II) or copper(I) and copper(II) complexes, such as azomethine bridge derivatives of the type represented by 10.160, of which numerous water-soluble or water-insoluble variants are possible [409]. These products have a catalytic action and are therefore used in very small amounts. 

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