Fp Compounds

Cyclopentadienylirondicarbonyl (Fp) Compounds. A common organoiron reagent is cyclo-pentadienylbis(carbonyliron) (Fp, 711). This derivative can be converted to an alkyl derivative (713, where R = alkyl) by reaction with an alkyl halide, or to the protio derivative (713, R = H) by reaction with an acid. The anionic reagent 712 is prepared by reaction of iron pentacarbonyl with the dimer of cyclopentadiene (710 - sec. 115.B) at 200°C to give the dimeric species 711. Treatment of 711 with base leads to loss of cyclopentadiene and formation of 712. A byproduct of this process is ferrocene (71 4) formed by extrusion of carbon monoxide from 711.595 

The protonated form of Fp can add to conjugated carbonyl derivatives such as acrylonitrile596 and also with conjugated dienes.597 Both S03598 and carbon monoxide can be inserted into the Fe—C bond of FpR.598 Protonolysis provides a synthetic route to substituted nitriles or alkenes. In each case the Fp unit can also be removed photochemically, thermally, or by treatment with triphenylphosphine. Hydride extraction to give an alkene or a diene is also known.599 

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As a mildly nucleophilic species, () -Allyl)Fp compounds have been shown to react with a fairly wide range of electrophilic species to give substituted () -alkene)Fp+ cations (79d-79m) (Scheme In general, HBF4... 

Oligosilanyl compounds of group 8 are a fairly well-studied class of compounds. In a series of papers Pannell and coworkers have continued their studies of the photochemistry of oligosilanyl Fp compounds [399 08]. The typical rearrangement behavior of these compounds involves formation of silyl silylene complexes followed by extrusion of a silylene (Scheme 35). The reversibility of these reactions can also cause rearrangements of the attached oligosilanyl groups. 

There is increasing evidence that the ionisation of the organic indicators of the same type, and previously thought to behave similarly, depends to some degree on their specific structures, thereby diminishing the generality of the derived scales of acidity. In the present case, the assumption that nitric acid behaves like organic indicators must be open to doubt. However, the and /fp scales are so different, and the correspondence of the acidity-dependence of nitration with so much better than with Hg, that the effectiveness of the nitronium ion is firmly established. The relationship between rates of nitration and was subsequently shown to hold up to about 82 % sulphuric acid for nitrobenzene, />-chloronitrobenzene, phenyltrimethylammonium ion, and p-tolyltrimethylammonium ion, and for various other compounds. ... 

The chlorination of a series of compounds having electron-withdrawing substituents has been studied. The relative rates of chlorination and the isomer distributions are known. The data give a satisfactory correlation with the Hammett equation using (t, but no rate measurement for benzene under precisely comparable conditions is possible. How could you estimate f,f y and fp for chlorination from the available data ... 

Triethylamine hydrochloride is separated by filtration and the filter cake is washed with 100 cc of anhydrous ethyl alcohol. The alcohol and the excess of triethylamine is distilled off in a vacuum of a water pump. The residue represents a light-yellowish brown viscous oil which is extracted 3 times with 500 cc of anhydrous benzene each time with stirring at 40° to 60°C. The benzene is distilled off on a water bath at 60°C. Thus, an oil is obtained which solidifies to a hard mass after some hours. This mass is crushed and dried over PjOs in an exsiccator. The compound represents N,N -bis-(3-hydroxypropyl)homo-piperazine. Yield 128.5 grams. FP 46°-47°C BPo.o2mm 141°-142°C. 

The interaction of butadiynediyl dimetal complexes [Fp -C -CsC-M, Fp =FeCp (CO)2, M= Fp, Rp, SiMea, Rp= RuCp(CO)2] with diiron nonacarbonyl, Fe2(CO)9, results in the formation of a mixture of products, as is also observed in the case of their interaction with organic acetylenes. Interesting polymetallic complexes, propargylidene-ketene compounds, zwitterionic cluster compounds, and pa-p -propargylidene-cyclobutene compoimds were isolated from the reaction mixtures and successfully characterized. The product distributions were found to be dependent on the metal fragment (M) at the other end of the C4 rod. The results of the reaction are described... 

The reactions of the butadiynediyldimetal(Fe, Ru) complexes with Fe2(CO)ci at room temperature afforded mixtures of products, from which three types of products, viz. the ps-acetylide cluster compound 4, the pj-ti -propargylidene-ketene compound 5 and zwitterionic cluster compound 6, were isolated. While the reaction with an excess amount of Co2(CO)g results in addition to the sterically congested Fp -C=C part [6]. The distributions of the products were dependent on the metal fragments situated at the other end of the conjugated carbon rod. The cluster compounds so obtained were characterized by spectroscopic and... 

Fig 4 In vitro nuclear receptor assays, a FP assay for compounds compete1aofc° tor... 

Figure 17 Src SH2 binding IC50 (Fp) for compound 25 (AP21773), which contains a bone-targeted, 4-diphosphonomethylphenylalanine (Dmp) pTyr mimic. (From Ref. 16.)...

Table 6 Src SH2 Binding (FP), Rabbit Pit, and Rat TPTX Data for Analogs of Compounds 27 and 35 (AP22209)... 

Kaloyanova FP, El Batawi MA. 1991. Organophosphorus compounds. In Human toxicology of pesticides. Boca Raton, FL CRC Press, 3-41. 

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