Forward thymidine kinase locus

The mouse lymphoma forward mutation test at the thymidine kinase locus (detects mutations to a nonfunctional thymidine kinase in a line of culture mouse lymphoma cells). [Pg.1011]

Oberly, T.J., Bewsey, B.J. Probst, G.S. (1985) Tests for the induction of forward mutation at the thymidine kinase locus of L5178Y mouse lymphoma cells in culture. Prog. Mutat. Res., 5, 569-582... [Pg.140]

Henry B, Grant SG, Klopman G, et al. 1998. Induction of forward mutations at the thymidine kinase locus of mouse lyphoma cells evidence for electrophilic and non-electrophilic mechanisms. Mutat Res 397(2) 313-335. [Pg.429]

Jotz, M.M. Mitchell, A.D. (1981) Effects of 20 coded chemicals on the forward mutation frequency at the thymidine kinase locus in L5178Y mouse lymphoma cells. In de Serres, F.J. Ashby, J., eds. Evaluation of Short-Term Tests for Carcinogens. Report of the International Collaborative Progrcm (Progress in Mutation Research, Vol. 1), Amsterdam, Elsevier, pp. 580-593... [Pg.540]

What is the potential of a test article with and without metabolic activation to induce forward mutations at the thymidine kinase locus of L5178Y TK+/-mouse lymphoma cells ... [Pg.896]

The forward mutation at the thymidine kinase (tk) locus of a mouse lymphoma cell line is measured by scoring resistance to trifluorothymidine (see Gebhart and Rossman 1991 for references). [Pg.438]

TABLE 9. Induced Forward Mutation Rates at the Thymidine Kinase (TK) Locus [TK —TK ... [Pg.91]

Big Chemical Encyclopedia