Formulation process high shear granulation

High-shear granulation has been one of the most commonly used methods to produce granules since the early 1980s (4). Hence, this chapter discusses in detail, the equipment, process variables, formulation requirements, granulation end-point determination, and scale-up considerations of the high-shear granulation process. 

An alternative to power consumption is torque measurement. A high-shear mixer was instrumented with a new capacitive sensor, a watt meter, and a strain-gauge torque sensor (50). Placebo formulations containing DCP, MCC 101, MCC 102, and lactose were granulated in the high-shear granulator. A similar map (profile of torque measurement or power consumption) of the granulation process was obtained for power consumption and torque measurement. 

Faure A, Grimsey IM, Rowe RC, York P, Cliff MJ. 1999. Process control in a high shear mixer-granulator using wet mass consistency the effect of formulation variables. J. Pharm. Sci. 88(2) 191-195. 

Lastly, note that the process or formulation itself cannot uniquely define whether it falls into a low- or high-agitation-intensity process. As discussed more fully below, it is a function of both the level of shear and the formulation deformability. A very stiff formulation with low deformability may behave as a low-deformabihty system in a high-shear mixer or a very pliable formulation may act as a high deformable system in a fluid-bed granulator. 

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