Formulation process granulation—extrusion—spheronization

In an extrusion-spheronization process, formulation components such as fillers, lubricants, and pH modifiers play a critical role in producing pellets with the desired attributes. The granulated mass must be plastic and sufficiently cohesive and self-lubricating during extrusion. During the spheronization step, it is essential that the extrudates break at appropriate length and have sufficient surface moisture to enhance formation of uniform spherical pellets. 

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