Formulation performance, response surface

In all formulations that have appeared in the literature thus far, a generalization of the CA reference concept was performed to statistically test for deviations from CA. This means that a function describing interaction is incorporated in the CA model such that if the interaction parameter is 0, the interaction function disappears from the function. This nested structure allows testing whether its appearance in the model improves the description of the data significantly by applying the likelihood ratio test. The various nonlinear response surface approaches do differ in the way this deviation function is formulated. 

It can be seen from these two figures that the response surface is saddle-shaped and has slightly more tilt at the low AI concentration. Overall they re very similar and show that active Ingredient of the purity range studied should perform satisfactorily in this formulation. 

Figure 2 clearly indicates that a captan wettable powder containing approximately 55% captan, 33% clay, 11% dispersant, and 1% surfactant should be evaluated if maximum suspensibility is desired. In addition to indicating regions of optimal composition, response-surface maps are extremely useful in analyzing cost vs. performance. Questions such as, "What is the most economical formulation that has 60% suspensibility " may be answered objectively, without additional experimentation. 

The discussion of the suggested method for reliability based optimization Is performed in terms of comparative calculations. For this purpose earlier formulations of the objective function are applied. Furthermore the system reliability analysis Is confined to first order analysis Instead of the more sophlstticated response surface approach. For a complete comparison local as well as global damage has to be taken into account. Therefore three formulations were chosen ... 

The responses chosen all relate to important foam properties. We believed that yi, the emulsion droplet size, determines y2, the cell size in the resultant foam, and we wished to determine whether this is true over this range of formulations. The foam pore size ys should determine the wetting rate y7, so these responses could be correlated, and yg, the BET surface area, should be related to these as well. The density y and density uniformity ys are critical to target performance as described above, and ys, the compressive modulus, is an important measure of the mechanical properties of the foam. 

The response contour surfaces for several key properties were generated using the mixture polynomial to highlight the performance differences of plastomer versus conventional EPR. The metallocene plastomer and EPR provided very similar impact enhancement in both notched Izod and instrumented Impact tests (Figs. 7.25 and 7.26). In all four cases, impact strength depended primarily on the impact modifier and less on the talc content. Flexural moduli were similar for plastomer and EPR compounds (Fig. 7.27). The plastomer formulations showed... 

The main future trends in additives are in response to legislative and commercial pressure. It is necessary to develop new compounds and master batches, which are nondusting, non-toxic, and easier to handle. The elimination of heavy metals and other hazardous ingredients is done by replacing them with alternative systems. Free-dust, free-solvent formulations reduce the risk of explosions. The performance will be improved by surface treatments of additives that create bonding with the matrix and the development of synergetic... 

---