Formation of Advanced Glycation Endproducts in Vivo

The modification by AGE of even less long-lived proteins is also possible. Makita et al.m were able to show by means of AGE-specific antibodies that circulating 

The Wolff pathway of oxidative glycosylation,400 initiated by the autoxidation of glucose to form reactive intermediates, such as arabinose and glyoxal.401 

The Namiki pathway, involving cleavage of the Schiff base, forming protein-bound aldehydes and glycolaldehyde and glyoxal.402 

The Hodge pathway, proceeding by oxidative cleavage of the Amadori compound.6 

There is evidence that the Wolff and Namiki pathways prevail in phosphate buffer in vitro, but the Hodge pathway may be important in vivo.403 40  

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