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Formamidopyrimidine-DNA glycosylase

The bacterial formamidopyrimidine-DNA glycosylase (alias Fpg or MutM) is a bifunctional base-repair enzyme (DNA glycosylase/AP lyase) that removes a wide range of oxidized purines from oxidatively damaged DNA. The crystal structures of the Fpg (MutM) enzymes from Thermus thermophilus, Lactococcus lactis Escherichia coli Bacillus stearothermophilus and the sequence similar endonuclease VIII (Nei) from E. all share the same... [Pg.5156]

Two structures incorporating modified nucleotides include the co-crystal structure of pseudouridine synthase TruB with a T stem-loop of tRNA in which the modification site (U55) is modified with 5-fluorouridine, " and the crystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to DNA containing an abasic site. " ... [Pg.497]

Chemistry and structural biology of DNA glycosylases the case ofthe formamidopyrimidine-DNA glycosylase (Fpg)... [Pg.227]

Castaing B., Boiteux S., Zelwer C., DNA containing a chemically reduced apurinic site is a high affinity ligand for the E. co//formamidopyrimidine-DNA glycosylase. Nucleic Acids Res., 1992,20,389-394. [Pg.232]

Serre L., Pereira de Jesus K., Boiteux S., Zelwer C., Castaing B., Crystal structure ofthe Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA, EMBO J., 2002,21,2854-2865. [Pg.232]

Boiteux, S., Gajewski, E., Laval, J., and Dizdaroglu, M. (1992) Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase) excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry, 31, 106-110. [Pg.74]

Food and Agriculture Organization of the United Nations formamidopyrimidine DNA glycosylase global genome nucleotide excision repair glutathione... [Pg.504]

OGGI" 8-oxoG-DNA glycosylase Removes oxidized and ring-opened purines including 8-oxoG and formamidopyrimidine... [Pg.504]

Other DNA glycosylases recognize and remove a variety of damaged bases, including formamidopyrimidine and 8-hydroxyguanine (both arising from purine oxidation), hypoxanthine (arising from adenine deamination), and alkylated bases such as 3-methyladenine and... [Pg.972]

Single-cell alkaline gel electrophoresis (the Comet assay) is a sensitive assay of DNA strand breaks. The Comet assay can be adapted to measure oxidative damage to DNA bases by measuring strand breaks induced by the treatment of DNA with relevant repair enzymes, eg., endonuclease III (EndoIII) for oxidized pyrimidines and formamidopyrimidine glycosylase (Fpg) for 8-oxogua and ring-opened pyrimidines, such as those resulting from the breakdown of alkylated bases. ... [Pg.334]

See other pages where Formamidopyrimidine-DNA glycosylase is mentioned: [Pg.505]    [Pg.5156]    [Pg.728]    [Pg.232]    [Pg.57]    [Pg.5155]    [Pg.596]    [Pg.386]    [Pg.336]    [Pg.337]    [Pg.718]    [Pg.199]    [Pg.497]    [Pg.167]    [Pg.505]    [Pg.5156]    [Pg.728]    [Pg.232]    [Pg.57]    [Pg.5155]    [Pg.596]    [Pg.386]    [Pg.336]    [Pg.337]    [Pg.718]    [Pg.199]    [Pg.497]    [Pg.167]    [Pg.340]    [Pg.972]    [Pg.1]    [Pg.650]    [Pg.131]    [Pg.17]    [Pg.167]   
See also in sourсe #XX -- [ Pg.596 ]



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DNA glycosylase

Formamidopyrimidine glycosylase

Formamidopyrimidine-DNA

Formamidopyrimidines

Glycosylases

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