Foods: Liver Coumarins

Beamand, J.A., Barton, P.T., Price, R.J. Lake, B.G (1998) Lack of effect of coumarin on unscheduled DNA synthesis in precision-cut human liver shces. Food chem. Toxicol., 36, 647-653... 

Goeger, D.E., Hsie, A.W. Anderson KE. (1999) Co-mutagenicity of coumarin (1,2-benzo-pyrone) with aflatoxin B1 and hnman liver S9 in mammalian cells. Food chem. Toxicol., 37, 581-589... 

Oxidative cellular damage by reactive oxygen species such as superoxide anion, hydroperoxy and hyassociated with various human chronic diseases, e.g. cancers, inflammation, arthritis, atherosclerosis and also with the process of ageing. Claims that diet and increased intake of nutrients exhibiting antioxidative activity have a preventative effect on chronic diseases have increased in recent years. In this context, polyphenolic compounds such as tannins, flavonoids, coumarins, lignans and caffeic acid derivatives, which are abundantly contained in a large number of medicinal plants, foods and beverages, are of particular interest for human health care because of the antioxidative properties widely found in plant phenolics. The antioxidative activity of tannins has been extensively studied in various in vitro and in vivo experimental systems and summarized in reviews [96, 97]. Such activity includes the inhibition of lipid peroxidation induced by NADPH-ADP and ascorbic acid-ADP in rat liver microsomes and mitochondria, respectively... 

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