Fondaparinux Aspirin

In healthy volunteers, steady-state fondaparinux did not alter the pharmacodynamic effects of a single dose of aspirin 975 mg (23). Aspirin did not alter the pharmacokinetics of fondaparinux. 

Ollier C, Faaij RA, Santoni A, Duvauchelle T, van Haard PM, Schoemaker RC, Cohen AF, de Greef R, Burggraaf J. Absence of interaction of fondaparinux sodium with aspirin and piroxicam in healthy male volunteers. Clin Pharmacokinet 2002 41(Suppl 2) 31-7. 

Clinically important, potentially hazardous interactions with aspirin, fondaparinux... 

A single 975-mg dose of aspirin given on day 4 of an 8-day course of subcutaneous fondaparinux 10 mg daily had no effect on fondaparinux pharmacokinetics in 16 healthy subjects. The increase in bleeding time with fondaparinux and aspirin was greater than with aspirin alone, but this was not statistically significant. Aspirin had no effect on the small prolongation of aPTT seen with fondaparinux. ... 

The pharmacological studies described show that the pharmacokinetics of fondaparinux are not changed by aspirin and piroxicam, and that there is only a minor increase in bleeding time. Nevertheless, the manufacturers of... 

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