Fonazine mesylate

Chemical Name 4-[3-[4-(phenoxvmethyl)phenyl] propyl] morpholine Common Name — 

64 parts of dry sodium phenolate are dissolved in 300 parts of methylisobutyl ketone by heating at 110°C. 103 parts of 7-(4-chloromethylphenyl)propyl chloride are added dropwise with agitation, and the mixture is maintained at 110°C for a period of 4 hours with constant agitation. After cooling, the reaction mixture is washed 2 or 3 times with 100 parts of water and the methylisobutyl ketone is distilled off under reduced pressure. The residue is taken up in 200 parts of petroleum-ether and 7-(4-phenoxymethylphenyl)propyl chloride is crystallized by addition of ice water. The crystals are filtered off employing a suction pump and dried at 100°C in vacuo (10 mm Hg) for 1 to 2 hours. The7-(4-phenoxymethylphenyl)propvl chloride melts at 55°C to 56°C after recrystallization from petroleum-ether. 

130 parts of 7-(4-phenoxymethylphenvl)propyl chloride are heated under reflux at 140°C for 24 hours with 130 parts of morpholine. The reaction mixture is treated to give N-(7-phenoxymethylphenyDpropyl] -morpholine, which forms colorless crystals melting at 52°C to 53°C when crystallized from n-heptane. 

Chemische Fabrik Promonta G.m.b.H. British Patent 786,128 November 13,1957 

Chemical Name 10-[2-(dimethylamino)propyl] -N,N-dimethylphenothiazine-2-sulfonamide methane sulfonate 

Trede Name Manufacturer Country Year Introduced 

---

On the addition of ethereal hydrogen chloride to a solution of the base in isopropanol and recrystallization from anhydrous ethanol of the salt formed, there is obtained 3-dimethyl-sulfamovl-10-(2-dimethvlaminopropyl)phenthiazine hydrochloride (2.1 grams), MP 214°C with decomposition. After dissolving the product in anhydrous ethanol and adding meth-anesulfonic acid there is obtained fonazine mesylate. 

Dimethylsulfamoylphenthiazime Fonazine mesylate Thioproperazine Dimethyl sulfate... 

Methanesulfonate, CjqH NjOjSj, dinttthothiazine mesylate, fonazine mesylate, Alius, Banistyl, Bonpac, Calsekin, Migristene, Neomestine, Promaquid, Yoristen. 

Dimethy lamino-2-chloropropane Fonazine mesylate Promethazine HCI... 

---