Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Folylpolyglutamate synthetase

Longo GS, Gorlick R, TongWP, Lin S, Steinherz P, Bertino IR (1997) Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias. Oncol Res 9 259-263... [Pg.653]

Barredo JC, Synold TW, Laver J, Relling MV, Pui CH, Priest DG et al (1994) Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia. Blood 84 564-569... [Pg.653]

Rots MG, Pieters R, Peters GI, Noordhuis P, van Zantwijk CH, Kaspers GI et al (1999) Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia. Blood 93 1677-1683... [Pg.653]

Salcedo, E., Cortese, J. F., Plowe, C. V., Sims, P. F., and Hyde, J. E. (2001). A bifunctional dihydrofolate synthetase-folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. Mol. Biochem. Parasitol. 112, 239-252. [Pg.374]

Figure 2 Biosynthesis of foiates. a, GTP cyclohydrolase I b, dihydroneopterin epimerase c, nudix hydrolase d, phosphatase e, dihydroneopterin aldolase f, hydroxymethyidihydropterin pyrophosphokinase g, dihydropteroate synthase h, dihydrofolate synthetase I, dihydrofolate reductase j, folylpolyglutamate synthetase k, aminodeoxychorismate synthase I, aminodeoxychorismate lyase. 7, 7,8-dihydro-D-neopterin 3 -triphosphate 8, 7,8-dihydro-L-monapterin 3 -triphosphate 9, 7,8-dihydro-D-neopterin 3 -monophosphate 10, 7,8-dihydro-D-neopterin 11, glycolaldehyde ... Figure 2 Biosynthesis of foiates. a, GTP cyclohydrolase I b, dihydroneopterin epimerase c, nudix hydrolase d, phosphatase e, dihydroneopterin aldolase f, hydroxymethyidihydropterin pyrophosphokinase g, dihydropteroate synthase h, dihydrofolate synthetase I, dihydrofolate reductase j, folylpolyglutamate synthetase k, aminodeoxychorismate synthase I, aminodeoxychorismate lyase. 7, 7,8-dihydro-D-neopterin 3 -triphosphate 8, 7,8-dihydro-L-monapterin 3 -triphosphate 9, 7,8-dihydro-D-neopterin 3 -monophosphate 10, 7,8-dihydro-D-neopterin 11, glycolaldehyde ...
Certain bacteria including E. coli form bifunctional enzymes with dihydrofolate and folylpolyglutamate synthetase (Figure 2, j) activityBoth the conversion of dihydropteroate into dihydrofolate and the subsequent attachment of additional glutamate moieties by the bifunctional E. coli enzyme have been shown to involve the transient formation of acyl phosphate intermediates. ... [Pg.611]

Folylpolyglutamate synthetases, including the bifunctional FolC proteins of bacterial origin, are members of a superfamily including the Mur proteins involved in bacterial cell wall biosynthesis. ... [Pg.613]

In assays of substrate activity for a partially purified folylpolyglutamate synthetase (FPGS) preparation from mouse liver, (IV. 164) had an apparent... [Pg.97]

In a recent study [246], the 2-aminobutyric acid analogue (VIII.21) was synthesized and reduced to H4-(VIII.21), which was tested as an inhibitor of hog liver folylpolyglutamate synthetase. The for inhibition of (65)-tetrahy-drofolate polyglutamylation was found to be 68 /iM, a value approximately 10-fold higher than the substrate for (6S)-tetrahydrofolate. This K JK ratio may be viewed as reflecting the deletion of the y-carboxyl group from the side-chain. [Pg.161]

An important property of the ornithine analogues (VIII.268) and (VIII.275) of MTX and AMT, respectively, was found to be their ability to inhibit folylpolyglutamate synthetase (FPGS) [369, 380]. Against partially purified FPGS from mouse liver [369], the MTX analogue (VIII.268) gave a of... [Pg.228]

D. Role of Folylpolyglutamate Synthetase Level in Folate Aocumula m... [Pg.95]

E. Role of Folylpolyglutamate Synthetase in Anti-folate Cytotoxidty... [Pg.95]

D. ROLE OF FOLYLPOLYGLUTAMATE SYNTHETASE LEVEL IN FOLATE ACCUMULATION... [Pg.101]

Table III shows the effect of folylpolyglutamate synthetase activity on the accumulation of folate and methotrexate, an antifolate drug, by CHO cell transfectants expressing levels of human folylpolyglutamate synthetase ranging from 2 to 1400% of wild-type CHO cells. Tissue culture cells express... Table III shows the effect of folylpolyglutamate synthetase activity on the accumulation of folate and methotrexate, an antifolate drug, by CHO cell transfectants expressing levels of human folylpolyglutamate synthetase ranging from 2 to 1400% of wild-type CHO cells. Tissue culture cells express...
Kinetic constants obtained with purified human folylpolyglutamate synthetase (unpublished data) were used to model folate accumulation and the derived data are compared with actual accumulation rates in Table IV. The data assume no competition between folate mono- and diglutamate... [Pg.102]

E. ROLE OF FOLYLPOLYGLUTAMATE SYNTHETASE IN ANTI-FOLATE CYTOTOXICITY... [Pg.104]

See other pages where Folylpolyglutamate synthetase is mentioned: [Pg.43]    [Pg.1016]    [Pg.148]    [Pg.1016]    [Pg.148]    [Pg.1016]    [Pg.43]    [Pg.653]    [Pg.274]    [Pg.613]    [Pg.42]    [Pg.74]    [Pg.85]    [Pg.125]    [Pg.132]    [Pg.150]    [Pg.162]    [Pg.169]    [Pg.179]    [Pg.870]    [Pg.97]    [Pg.98]    [Pg.99]    [Pg.99]    [Pg.100]    [Pg.100]    [Pg.101]    [Pg.101]    [Pg.102]    [Pg.103]    [Pg.103]    [Pg.104]   
See also in sourсe #XX -- [ Pg.40 , Pg.97 , Pg.98 , Pg.99 , Pg.100 ]

See also in sourсe #XX -- [ Pg.97 , Pg.98 , Pg.153 , Pg.154 , Pg.162 , Pg.164 , Pg.165 , Pg.168 , Pg.171 ]

See also in sourсe #XX -- [ Pg.97 , Pg.98 , Pg.99 , Pg.100 ]



SEARCH



Folylpolyglutamates

© 2024 chempedia.info