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Folate folylpolyglutamate synthetase

D. Role of Folylpolyglutamate Synthetase Level in Folate Aocumula m... [Pg.95]

E. Role of Folylpolyglutamate Synthetase in Anti-folate Cytotoxidty... [Pg.95]

D. ROLE OF FOLYLPOLYGLUTAMATE SYNTHETASE LEVEL IN FOLATE ACCUMULATION... [Pg.101]

Table III shows the effect of folylpolyglutamate synthetase activity on the accumulation of folate and methotrexate, an antifolate drug, by CHO cell transfectants expressing levels of human folylpolyglutamate synthetase ranging from 2 to 1400% of wild-type CHO cells. Tissue culture cells express... Table III shows the effect of folylpolyglutamate synthetase activity on the accumulation of folate and methotrexate, an antifolate drug, by CHO cell transfectants expressing levels of human folylpolyglutamate synthetase ranging from 2 to 1400% of wild-type CHO cells. Tissue culture cells express...
Kinetic constants obtained with purified human folylpolyglutamate synthetase (unpublished data) were used to model folate accumulation and the derived data are compared with actual accumulation rates in Table IV. The data assume no competition between folate mono- and diglutamate... [Pg.102]

E. ROLE OF FOLYLPOLYGLUTAMATE SYNTHETASE IN ANTI-FOLATE CYTOTOXICITY... [Pg.104]

Kim, J.-S., Lowe, K. E., and Shane, B. (1993). Regulation of folate and one carbon metabolism in mammalian cells. 4. Role of folylpolyglutamate synthetase in antifolate metabolism and cytotoxicity. J. Biol. Chem. 268, 21 0-21685. [Pg.105]

Taylor, R. T., and Hanna, M. L. (1977). Folate-dependent enzymes in cultured Chinese hamster ovary cells Folylpolyglutamate synthetase and its absence in mutants auxotrophic for glycine + adenosine -i- thymidine. Arch. Biochem. Biophys. 181,331-344. [Pg.106]

See other pages where Folate folylpolyglutamate synthetase is mentioned: [Pg.43]    [Pg.148]    [Pg.148]    [Pg.43]    [Pg.613]    [Pg.74]    [Pg.162]    [Pg.179]    [Pg.870]    [Pg.97]    [Pg.98]    [Pg.99]    [Pg.99]    [Pg.100]    [Pg.100]    [Pg.101]    [Pg.101]    [Pg.102]    [Pg.103]    [Pg.103]    [Pg.105]    [Pg.215]    [Pg.585]    [Pg.941]   
See also in sourсe #XX -- [ Pg.40 , Pg.97 , Pg.98 , Pg.99 , Pg.100 ]



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Folylpolyglutamates

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