Folliculogenesis

After ovulation, the walls of the follicular cavity in the ovary develop into the corpus luteum, which persists if fertilization occurs or disintegrates if fertilization does not occur. In addition to triggering ovulation, the mid-cycle surge in LH induces luteinization of the thecal and granulosa cells of die follicle wall. Normal luteal function depends upon both normal folliculogenesis and successful follicular rupture. Vascularization of the follicle wall with ovulation makes it possible for the luteinized thecal and granulosa cells to access low-density 

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Aromatase inhibitors have also been used in premenopausal women for the treatment of endometriosis and to induce ovarian folliculogenesis as part of the treatment for infertility. 

Hillier, S. (1994). Current concepts of the role of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Hum. Reprod. 9(2), 188-191. 

Bl. Balakier, H., and Stronell, R. D., Color Doppler assessment of folliculogenesis in in vitro fertilization patients. Fertil. Steril. 62, 1211—1216 (1994). 

Follicle bioassay (mouse) FBA Ovarian function Oogenesis polar body oocytes on day 13 upon ovulatory stimulus Folliculogenesis and oogenesis... 

Messinis, I.E., Krishnan, M., Kazem, R., Khadilkar, S. and Templeton, A.A. (1997) Effed of mifepristone on folliculogenesis in women treated with, recombinant FSH. Clinical Endocrinology (Chford), 46, 309-314. 

Ovarian follicular and luteal cells contain PGE2 (6) and PGF (5) receptors. The PG receptors are able to affect target cell functions through the cAMP/protein kinase A (PKA)-, phosphatidylinositol-specific phospholipase C (PLC)- and protein kinase C (PKC)-dependent intracellular mechanisms (1,7). In epididymis, the effects of PGE on local cAMP have been described (18). There is indirect evidence that in the male reproductive system, PGE can facilitate sperm transport and acrosome reaction (1) however, only one function of PG in male reproductive system, the involvement of PGE in epididymal water/electrolyte metabolism, has been documented to date (18). In the female reproductive processes, PGE participates in ovulation and fertilization (6), whereas PGF is a potent regulator of ovarian folliculogenesis, ovula-... 

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