Folic acid, conjugation with

Figure 8.18 (a) An example of folic acid conjugated with PU, using LDI, and 1,5-pentane diol based PU-urea system, (b) PU-conjugated anticancer drug (oxaplatin) delivery to specific lactose receptor, overexpressed in cancer cells. Lactobionic acid (targeting moiety). 

Fig. 10.14 Folic acid can be conjugated onto nanotubes fluorescently labeled nanotubes to target cells expressing folic acid receptors (a,b,c). Nanotubes conjugated with folic acid display a fluorescent signature indicating that nanotubes are internalized by cells expressing folic acid receptors (d). Without the folic acid conjugate, there is very little distribution of nanotubes within the cells as attributed by the lack of fluorescent signature in (e) (Reprinted from Kam et al., 2005. With permission from the National Academy of Sciences, USA) (See Color Plates)...

EC145 (A5), a folic acid conjugate of desacetyl vinblastine monohydrazide, represents a new generation of receptor-specific targeted chemotherapy and is undergoing Phase I anticancer clinical trials (19). Phase II trials for bladder and kidney cancers are underway with vinflunine (A6), a bifluorinated vinorelbine derivative (20, 21). 

Figure 5.11 Folic acid-conjugated graphene oxide loaded with photosensitizers Ce6 for targeting and killing of tumor ceU. Reproduced with permission from [167].

A strain of Corynebacterium which produces a folic acid derivative was the source of the material used for many of the structural studies on foUc acid and its derivatives, and this fermentation factor was found to be fohc acid conjugated with an additional two glutamic acid units . 

Teng Z, Luo Y, Wang X Zhang B, Wang Q (2013b). Development and application of nanoparticles synthesized with folic acid conjugated soy protein./40ric Food Chem, 61,2556-2564. 

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