Folate bioavailability

Gregory, J.F., Quinlivan, E.P., and Davis, S.R. (2005). Integrated the issues of folate bioavailability, intake and metabolism in the era of fortification. Trends FoodSci Tech.l6,229-240. 

Gregory JF 3rd (2001) Case study folate bioavailability./oMmfl/o/JVMrrtft ow 131,1376S-82S. 

Bailey, L. B. (1988). Factors affecting folate bioavailability. Food Technol. (Oct.) 42,206-238. 

Gregory JF III. Case Study Folate bioavailability. J Nutr 2001 131 1376S-82S. 

Sanderson P, McNulty H, Mastroiacovo P, McDowell IF, Melse-Boonstra A, Finglas PM, Gregory JF, III. Folate bioavailability UK Food Standards Agency workshop report. Br J Nutr 2003 90 473-9. 

Considerable uncertainty and controversy exists concerning the folate requirement for humans. Hie review of data concerning the human folate requirement by the Food and Nutrition Board (1989) suggests that the daily maintenance requirement is 100-200 fig of avaUable folic acid equivalents. The 1989 RDAs were reduced to 200 and 180 fig for adult men and women, respectively, from the previous RDA of 400 on the basis of such evidence (Food and Nutrition Board, 1989). Similarly, the Canadian RDA for folate was set at 3 /ig/kg body wt or 210 fig for a 70-kg individual. These lower RDAs may be inadequate for certain population groups, however (Sauberlich, 1990 Bailey, 1992 McPartlin etai, 1 3). It is currently difficult or impossible to predict the quantitative effect on folate nutritional status of factors such as (a) changes in folate intake, (b) differences in folate bioavailability, (c) effects of pregnancy and lactation on folate requirements, and (d) pharmaceuticals with antifolate properties. In addition, the development of mathematical models would improve our ability to evaluate methods of nutritional status assessment for this vitamin. 

Rychlik, M., Netzel, M., Pfannebecker, I., Frank, T., and Bitsch, I., 2003. Application of stable isotope dilution assays based on liquid chromatography-tandem mass spectrometry for the assessment of folate bioavailability. Journal of Chromatography B. 792 167-176. 

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