Focus on Catalyst Development and Ligand Design

Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 

The Mizoioki-Heck reaction was discovered more than 35 years ago [1, 2] since then, it has been recognized as one of the most fundamental types of the organic processes catalysed by palladium complexes. 

For any general transition metal-catalysed process, researchers seek to achieve protocols which  

Even a very brief analysis of publications on Mizoroki-Heck reactions reveals immediately that the goals of researchers in this area fit well into this paradigm. However, it is rather apparent that these goals have not been achieved so far by any particular protocol, or by a compact group of protocols. Very impressive results on, say, catalytic efficiency are obtained for a very narrow subset of substrates (aryl iodides and reactive aryl bromides 

The Mizoroki—Heck Reaction Edited by Martin Oestreich 2009 John Wiley Sons. Ltd. ISBN 978-0-470-03394-4 

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