Fluvoxamine properties

Benca RM, Obermeyer WH, Thisted RA, et al Sleep and psychiatric disorders a metaanalysis. Arch Gen Psychiatry 49 651-668, 1992 Benfield P, Ward A Fluvoxamine a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in depressive illness. Drugs 32 313-334, 1986... 

Bradford LD, Coleman BS, Hoeve L. Summary of the properties of fluvoxamine maleate. Duphar Report no. H114.058. 1984. 

Broom 2. Ginkgo biloba 3. Scopolia 4. Yohimbine 1. TCAs (e.g. amitriptyline, nortriptyline, clomipramine) 2. SSRIs (e.g. fluvoxamine fluoxetine, paroxetine) 3. Venlafaxine 4. Trazodone May develop cardiac arrhythmias and side-effects such as dryness of the mouth, retention of urine and tachycardia, t sedation Broom contains cardioactive alkalamines such as sparteine Inhibits metabolizing enzymes Anticholinergic properties (hyoscine present in scopolia may worsen side-effects of TCAs-additive antimuscarinic effects) Yohimbine alone can cause hypertension, but lower doses cause hypertension when combined with TCAs Unknown mechanism (ginkgo t sedative effects of trazodone) St John s wort inhibits the uptake of serotonin and thereby t serotonin levels Avoid concomitant use. An SSRI may be a better alternative to be used with broom... 

Fluvoxamine also has antagonist properties at sigma 1 receptors... 

Fluvoxamine s sigma f antagonist properties may contribute to sedation and fatigue in some patients... 

Fluvoxamine, an antidepressant, is a potent and selective serotonin reuptake inhibitor (see Figure 86) which is devoid of anticholinergic, antihistaminic, or cardiotoxic properties. Fluvoxamine offers depressed patients an equivalent level of therapeutic benefit when compared with imipramine (see Tables 5 through 7). 

---