Flutamide Alcohol

The adverse effects of antiandrogens are gynecomastia, hot flushes, GI disturbances, liver function test abnormalities, and breast tenderness. GI disturbances consist of diarrhea for flutamide and bicalutamide and nausea or constipation for nilutamide. Flutamide is also associated with methemoglobinemia, whereas nilutamide causes visual disturbances (impaired dark adaptation), alcohol intolerance, and interstitial pneumonitis. 

Alcohol intolerance (facial flushing, malaise, hypotension) has been reported in patients receiving nilutamide but not bicalutamide or flutamide. 

Flutamide and bicalutamide have not been reported to produce these effects when patients drink alcohol, so they may be considered as an alternative option to nilutamide. 

The determination of flutamide in either pure form or in its pharmaceutical preparations can be performed with the aid of two different processes (1) the diazotization of reduced flutamide, followed by coupling with alcoholic iminodi benzyl in acid medium to give a purple-colored product having a maximum at 570 nm or (2) diazotization of the reduced flutamide and coupling it with 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid monosodium salt in a buffer medium of pH 12, which gives a red-colored... 

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