Triethyl-lead fluoroacetate

Class B Fluoroacetic acid and salts, e.g. sodium fluoroacetate, triethyl-lead fluoroacetate all simple esters of fluoroacetic acid fluoroacetamide and substituted amides fluoroacetamidine hydrochloride fluoroacetyl chloride and fluoride fluoro-ethanol and its simple esters fluoroacetaldehyde. 

It has been shown that trialkyl-lead salts have marked sternutatory action3 when dispersed as a particulate cloud.4 Triethyl-lead fluoroacetate, CH2F C02PbEt3, was therefore prepared with the idea of combining sternutatory action with fluoroacetate-like activity. The compound, a stable, highly crystalline material, was readily prepared by the action of fluoroacetic acid on tetraethyl-lead in the presence of silica gel. As a sternutator it proved to be similar in action to that of the... 

Combination of fluoroacetate activity and certain other recognizable physiological effects have been successfully combined in fluoroaspirin (drugged sleep), triethyl-lead fluoroacetate (sternutation), difluoroethyl phosphorofluoridate (myosis, but not powerful). In general, quaternary ammonium... 

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