1-Fluoro naphthalene

Et4N F ... SHF is a more convenient depolarizer for general use. In the presence of this complex at an anode potential of +1.6 to +1.8 V, naphthalene yields 1-fluoro- (27%) and 1,4-difluoro-naphthalene (3%), 1-fluoro-naphthalene gives 1,4-difluoronaphthalene (40%), and 1,4-difluoronaphthalene gives the addition compound (8) (22%) with traces of 1,2,3-trifluoro-and 1,2,3,4-tetrafluoro-naphthalene. Two one-electron transfer steps arc suggested for each fluorination stage of the reaction e.g. Scheme 3) and the... 

The "/(F-C) values in 1-fluoro and in 2-fluoro-naphthalene have been measured by Ernst (158) and by Doddrell et al. (153) Although their values for 1-fluoronaphthalene agree, there are a number of discrepancies concerning the assignment of the various carbon resonances in 2-fluoronaphthalene. 

Fluoro-naphthalene Insoluble at boiling point, some swelling... 

Fluoronaphthalene [321-38-0] is prepared from 1-naphthylamine by the Balz-Schiemaim reaction in 52% yield or by diazotization in anhydrous hydrogen fluoride in 82% yield. Electrophilic substitution occurs at the 4-position, eg, nitration with fuming nitric acid in acetic acid gave 88% yield of l-fluoro-4-nitro-naphthalene [341 -92-4]. 

A further difficulty in the case of fluoro-, chloro- and bromobenzenes is that with them apparently no choice of the 8 values seems to be reconcilable with the observed order of ease of substitution at the various positions unsubstituted benzene > para > ortho > meta. Both the inductive and the resonance effects are seen to leave the charge on the w-position practically unchanged, and approximately equal to 1.00c, while the observed order demands a considerably smaller value. As in the case of naphthalene, however, we shall find later that this discrepancy can apparently be explained by taking into account the polarization of the molecule by the attacking group. 

Amphetamine-related compounds 4-Fluoro-7 -nitrobenzoxadiazole Naphthalene-2,3-dicarboxaldehyde 76, 77... 

Figure 14 Representative fluorescence derivatization reagents used for PO-CL detection. DNS-CI, dansyl chloride DBD-F, 4-(A,A-dimethylaminosulphonyl-7-fluoro-2,l, 3-benzoxadiazole NDA, naphthalene-2,3-dicarboxaldehyde DNS-H, dansyl hydrazine DBD-H, 4-(iV,iV-dimethylaminosulphonyl-7-hydrazino-2,l,3-benzoxadiazole).

Naphthalene-2,3-dicarboxaldehyde Nicotinamide adenine dinucleotide N-Acetylneuraminic acid 4-Fluoro-7-nitrobenzoxadiazole Naphthalene-2,3-dicarboxaldehyde Nondestructive readout Near infrared Near infrared fluorescence Nuclear magnetic resonance 2-Nitrophenyl oxalate 1,1 -Oxalyldiimidazole Polycyclic aromatic hydrocarbon Principal component analysis Photosensitized chemiluminescence Pentachlorophenyl oxalate Polymerase chain reaction... 

Kinetic parameters of metabolism of fluorinated analogues of propanolol by cytochrome enzyme (recombinant CYP1A2) have been determined. They clearly indicate that the A-dealkylation process was 10-fold lower for the N—CH2CF3 compound with respect to propanolol itself. Hydroxylation of the naphthalene ring process is not observed in the case of propanolol but it becomes the major process with the fluoro analogue (Figure 3.13)." The same decreased metabohsm trend has also been observed with lower pKa values for CYP2D6 cytochrome enzyme." ... 

Aromatic compounds can participate in both [2+2] and [4+2] photocycloaddition reactions with uracil derivatives to give either benzocyclobutane or ethenoquinazoline (barrelene) derivatives, which can then undergo a number of subsequent photochemical reactions. The products obtained are dependent upon the reaction conditions, and thus the photocycloaddition reaction between naphthalenes 470 and l,3-dimethyl-5-fluorouracil 471 in cyclohexane gave 4a-fluoro-5,10-ethenobenzo[/]quinazolines 472 as products as a result of a [4+2] photocycloaddition (photo-Diels-Alder) reaction <2002TL3113, 2003H(61)377>. 

Reaction of naphthalene, anthracene and pyrene derivatives with trifluoromethyl hypofluorite at — 78 C results mainly in fluoro-substituted products 36 and difluoro ketones 37. The ratio between the two types of products depends on the substituents and the structure of the aromatic molecule.58-61... 

Sodium bis(2-methoxyethoxy)aluminum hydride (S)-6-Fluoro-l-isopropyl-3,4-dihydro-lH-naphthalen-2-one... 

To the mixture 22.7 g (0.54 mol) dry lithium chloride and 100 mL THF at -15°C was added 160 mL 2 molar lithium diisopropylamide (0.32 mol) in heptane/THF/ethylbenzene was added. Then a solution of 36.6 g (0.16 mol) N-[3-(lH-benzimidazol-2-yl)-propyl]-N-methylacetamide in 140 mL toluene was added, the solution was stirred for 2 hours, and a further 155 mL toluene was added. (S)-6-Fluoro-l-isopropyl-3,4-dihydro-lH-naphthalen-2-one (29.9 g, 0.15 mol), in 15 mL toluene was added. After stirring at -10°C for 4 hours, the resulting solution was added to 200 mL ice water. The pH of the resulting mixture was adjusted to 7-8 by addition of a 71 g concentrated hydrochloric acid. The organic layer washed with water, then the solvents removed under reduced pressure to give 96 g of (lS,2S)-N-[3-(lH-benzimidazol-2-yl)propyl]-... 

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