3 -Fluoro-3 -deoxythymidine

Frijus-Plessen, N. Michaelis, H.C. Foth, H. Kahl, G.F. Determination of 3 -azido-3 -deoxythymidine, 2, 3 -dideoxycytidine, 3 -fluoro-3 -deoxythymidine and 2, 3 -dideo grinosine in biological samples by higb-performance Uquid chromatography. J.Chromatogr., 1990, 534, 101—107... 

The 4-methylthio analogue and some hydantoin analogues of 3 -fluoro-3 -deoxythymidine (FLT) have been prepared by condensation methods. 

Immunodeficiency Virus Agent 3 -Fluoro-3 -deoxythymidine and Electronic Charge Calculations for 3 -Deoxythymidines, Proc. Natl. Acad. Sci. U.SA. 87 3534 (1990). 

Fig. 3. Metabolism of the fluoropyrimidines dTMP = deoxythymidine monophosphate, dUMP = deoxyuridine monophosphate, FdUDP = fluorodeoxyuridine diphosphate, FdUMP - fluoro-deoxyuridine monophosphate, FdUTP = fluorodeoxyuridine triphosphate, FU-DNA= fluorouracil-deoxyribonucleic acid, FUDP = fluorouracil diphosphate, FUMP = fluorouracil monophosphate, FU-RNA = fluorouracil-ribonucleic acid, FUTP = fluorouracil triphosphate.

M. Wagner, U. Seitz, A. Buck, B. Neumaier, S. Schultheiss, M. Bangerter, M. Bommer, F. Leithauser, E. Wawra, G. Munzert, S.N. Reske, 3 -[ F]fluoro-3 -deoxythymidine ([ F]-FLT) as positron emission tomography tracer for imaging... 

Benzyl 3-bromo-3-deoxy-2-0-methyl-p-D-xylopyranoside, B-103 Benzyl 3-bromo-3-deoxy-4-0-methyl-p-D-xylopyranoside, B-103 Benzyl 3-deoxy-3-fluoro-p-D-glucopyranoside, D-89 Benzyl 3-deoxy-3-iodo-p-L-xylopyranoside, D-280 Benzyl 2,4-di-D-benzoyl-3-bromo-3-deoxy-a-D-xylopyranoside, B-103 Benzyl 2,4,6-tri-D-acetyl-3-deoxy-3-fluoro-p-D-glucopyranoside, D-89 1 - O -Benzyl-3-deoxy-3-fluoro-D-fructose, D-74 3-Bromo-3-deoxy-l,2 5,6-di-0-isopropylidene-a-D-allofuranose, B-56 3-Bromo-3-deoxyglucose D-form, B-75 3-Bromo-3-deoxymannose D-form, B-88 3 -Bromo-3 -deoxythymidine 5 -Trityl, B-99 3 -Bromo-3 -deoxythymidine, B-99... 

Azido-5-bromo-2, 3 -dideoxyuridine, A-894 3 -Azido-5-chloro-2, 3 -dideoxycytidine, A-895 3 -Azido-5-chloro-2, 3 -dideoxyuridine, A-896 6-Azido-6-deoxyfructose D-form, A-901 2-Azido-2-deoxygalactose p-D-Pyranose-ybrm, A-903 2-Azido-2-deoxyglucopyranosyl bromide d-D-form, A-905 2-Azido-2-deoxyglucose D-form, A-908 2-Azido-2-deoxymannose D-form, A-912 6-Azido-6-deoxymaimose D-form, A-913 5 -Azido-5 -deoxythymidine 3 -Ac, A-915 5 -Azido-5 -deoxythymidine, A-915 3 -Azido-3 -deoxy-5 -thymidylic add, 9CI, Z-4 6-Azido- 3,4-di-O -benzy 1-6-deoxy-p-D-fructofuranose, A-901 l-(3-Azido-2,3-dideoxy-2-fluoro-p-D-arabinofuranosyl)thymine, A-917 2 -Azido-2, 3 -dideoxy-5-iodouridine, A-920 2 -Azido-2, 3 -dideoxy-5-methyluridine, A-922 2 -Azido-2, 3 -dideoxyuridine, A-923 4 -Azidothymidine, A-926 Cellobiosyl azide a-D-form Hepta-Ac, C-39 Cellobiosyl azide D-form Hepta-Ac, C-39 Cellobiosyl azide D-form, C-39 Cytarazid, C-199... 

In their initial work, these authors reported a poten-tiometric study on the ability of the Zn " " complex of cyclen (80) to interact with the deoxyribonucleotides 2 -deoxyadenosine (dA), 2 -deoxyguanosine (dG), 2 -deoxy-cytidine (dC), 2 -deoxythymidine (dT), uridine (U), and 3 -azido-3 - deoxythymidine (AZT). [Zn(80)] " had a good selectivity for dT, U, AZT, and the related derivatives Ff (ftorafur, 5-fluoro-l-(tetrahydro-2-furyl)uracil), and... 

The thiazolidinyl analogue 202 of pseudouridine, and its enantiomer, have been made, with chirality originating in d- or L-cysteine, ° whilst thiazolidinones 203 (B=Cyt, Thy, 5-fluoro-Cyt) have been prepared, using Pummerer-type chemistry. 4 -Azathymidine derivatives such as 204 have been prepared by cycloadditions of nitrones with vinyl acetate, followed by base- sugar condensation, and the isoxazolidinyl nucleoside 205, and its trans-isomer, have been made as racemates. The N-in-ring analogue 206 of 3 -deoxythymidine has... 

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