Fluorinated Functions and Motifs in Medicinal Chemistry

Several formulations based on perfluorodecalin, perfluoropropylamine, and per-fluorobutylamine are marketed or in development ifluorosol, perfluoran, fluxon, oncosol, oxyfluor, oxygent). 

In most of cases, the fluorine atom(s) or the CF3 group(s) is borne by aromatic rings. Synthesis of these compounds for the optimization of hits as well as for parallel synthesis is done using the numerous fluoro aromatic or heterocyclic compounds that are commercially available. These latter compounds generally come from aromatic fluorination or trifluoromethylation reactions (especially the Balz-Schiemann reaction) and from heterocyclization reactions. However, fluoroaliphatic chains and fluorofunctionalities are more and more present, because of their pharmacological properties. Some examples are given in this section. 

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