Fluorescence polymer latex bead

Another example of a delivery system based on microbubbles and ultrasound is the delivery of circulating microparticles (polymer latex beads) or fluorescent red blood cells outside of the capillaries into the surrounding tissues by the action of ultrasound on the co-injected Optison microbubbles [79]. Interestingly, polymer beads and red blood cells could be detected tens of micrometers away from the capillaries where the bubble destruction took place. This may imply that during rapid destruction of a microbubble in a very strong ultrasound field, adjacent microsphere beads in the bloodstream can be propelled deep into the surrounding tissues. 

Syntheses of different types of latex particles by emulsion polymerization that differ in particle size, polymer hydrophificity, and surface coverage with functional groups were presented by Paulke et al. [51 ]. The particles were equipped with intensive fluorescence. Concentrated particle suspensions were injected into the brain tissue of mice and the effect of two kinds of beads is shown in brain sections. The same research group [52] presented a very different work on electrophoretic three-dimensional (3D)-mobility profiles of latex particles with different surface groups. In particular, hydroxyl functions were studied in different surroundings. The latexes gave model colloids with different electrophoretic behavior in comparison with classical anionic monodisperse PS latex particles. 

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