Fluconazole Aminophylline

Clinically important, potentially hazardous interactions with alfentanil, aminophylline, amisulpride, amoxicillin, ampicillin, anticonvulsants, astemizole, atorvastatin, benzodiazepines, bromocriptine, buprenorphine, bupropion, carbamazepine, cilostazol, ciprofloxacin, cisapride, clindamycin, colchicine, cyclosporine, dasatinib, digoxin, dihydroergotamine, diltiazem, disopyramide, enoxacin, eplerenone, ergotamine, eszopiclone, everolimus, fluconazole, fluoxetine, fluvastatin, gatifloxacin, HMG-CoA reductase inhibitors, imatinib, itraconazole, ketoconazole, lomefloxacin, lorazepam, lovastatin, methadone, methylprednisolone, methysergide, midazolam, mizolastine, moxifloxacin, nitrazepam, norfloxacin, ofloxacin, paroxetine, pimozide, pravastatin, quinolones, ranolazine, repaglinide, rupatadine, sertraline, sildenafil, simvastatin, sparfloxacin, sulpiride, tacrolimus, terfenadine, triazolam, troleandomycin, vardenafil, verapamil, vinblastine, warfarin, zaleplon, zolpidem, zuclopenthixol... 

Johnson, C.E. Jacobson, P.A. Pillen, H.A. Woycik, C.L. Stability and compatibility of fluconazole and aminophylline in intravenous admixtures. Am.J.Hosp.Pharm., 1993, 50, 703—706 [stability-indicating UK-48-134 (IS) saline 5% dextrose non-interfering aminophylline]... 

A crossover study in 5 healthy subjects found that fluconazole 100 mg given every 12 hours for 7 doses caused only a non-significant 16% decrease in the clearance of a single 300-mg ord dose of aminophylline. Another study in 10 healthy subjects found that fluconazole 100 mg daily for one week had no significant effect on the serum levels of theophylline 150 mg twice daily The clearance of a single 6-mg/kg oral dose of theophylline was reduced by 13.4% in 9 subjects who took fluconazole 400 mg daily for 10 days. In contrast, an isolated and brief report says that one of 2 patients given theophylline and fluconazole had a rise (amount not specified) in serum theophylline levels. ... 

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See also in sourсe #XX -- [ ]

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