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Flavonoids with chemopreventive activities

The application of flavonoids for the treatment of various diseases associated with free radical overproduction is considered in Chapter 29. However, it seems useful to discuss here some studies describing the activity of flavonoids under certain pathophysiological conditions. Oral pretreatment with rutin of rats, in which gastric lesions were induced by the administration of 100% ethanol, resulted in the reduction of the area of gastric lesions [157]. Rutin was found to be an effective inhibitor of TBAR products in the gastric mucosa induced by 50%i ethanol [158]. Rutin and quercetin were active in the reduction of azoxymethanol-induced colonic neoplasma and focal area of dysplasia in the mice [159], Chemopreventive effects of quercetin and rutin were also shown in normal and azoxymethane-treated mouse colon [160]. Flavonoids exhibited radioprotective effect on 7-ray irradiated mice [161], which was correlated with their antioxidative activity. Dietary flavones and flavonols protected against the toxicity of the environmental contaminant dioxin [162], Rutin inhibited ovariectomy-induced osteopenia in rats [163],... [Pg.867]

The predominant effect of flavonoid and isoflavonoid supplementation in ex vivo cell culture models appears to be one of promoting apoptosis [54—57]. This is repeatedly observed in studies witti transformed cancer cells, leading to the descriptions cytoprotective and/or chemopreventive [6,58]. Two poly-phenolic compounds that have been extensively studied in anticancer research are quercetin and genistein, a flavonoid and isoflavone, respectively. However, ex vivo studies with primary cultured cells in 2000 and 2001 showed that some flavonoids can prevent apoptosis promoted by agents that induce oxidative stress [7,8,59]. The outcome of flavonoid treatment is expected to show a complex dependence on a number of factors, including the type of flavonoid, its concentration, the type of cell (e.g., transformed versus nontransformed), the mechanisms of action of the flavonoid, the nature of the proapoptotic stimulus, and the specific apoptotic signaling pathway that is activated. [Pg.294]


See other pages where Flavonoids with chemopreventive activities is mentioned: [Pg.79]    [Pg.92]    [Pg.59]    [Pg.79]    [Pg.92]    [Pg.59]    [Pg.2191]    [Pg.2212]    [Pg.24]    [Pg.2181]    [Pg.2190]    [Pg.298]    [Pg.473]    [Pg.1021]    [Pg.29]    [Pg.33]    [Pg.80]    [Pg.93]    [Pg.1361]    [Pg.754]    [Pg.215]    [Pg.406]    [Pg.409]    [Pg.21]    [Pg.241]    [Pg.269]    [Pg.207]    [Pg.2187]    [Pg.2195]    [Pg.2209]    [Pg.2223]    [Pg.2328]    [Pg.30]    [Pg.50]   
See also in sourсe #XX -- [ Pg.92 ]




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