FKBP FK506 Binding Proteins

Wulfing, C., Lombardero, J. and Pluckthun, A. (1994) An Escherichia coli protein consisting of a domain homologous to FK506-binding proteins (FKBP) and a new metal binding motif. Journal of Biological Chemistry 269, 2895-2901. 

Kay, J. E. (1996). Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases. Biochem.J. 314, 361-385. 

The experimental determination of Aff and AS sometimes yields surprising results, as, for example, in the thermodynamics of hydrogen-bond formation in the complex of FK506 or rapamycin with FK506-binding protein (FKBP). " Binding to the wild-type and to the mutant Tyr 82 Phe 82 was... 

There are several examples that illustrate the potential of SAR by NMR. As noted earlier, FK506 binding protein (FKBP) inhibits cal-cineurin and blocks T-cell activation when complexedtothe immunosuppressant FK506. This protein was used as a target for SAR by... 

Fischer, S., Michnick, S. and Karplus, M. (1993) A Mechanism for Rotamase Catalysis by the FK506 Binding Protein (FKBP), Biochemistry 32, 13830-13837. 

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