Fixed dose combination antiretrovirals

O Brien DP, Sauvageot D, Zachariah R, Humblet P. In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy. AIDS 2006 20(I5) 1955-60. 

Temesgen Z. Cobidstat-boosted elvitegravir-based fixed-dose combination antiretroviral therapy for HIV infection. Drugs Today (Bare) 2012 48(12) 765-71. 

Applications are also encouraged for fixed-dose combinations of any first-line ARV regimens as described in the WHO Guidelines for Scaling Up Antiretroviral Therapy in Resource Umited Settings - 2003 Revision. For further information please consult ... 

Currently, there are six classes of antiretroviral agents, with 25 approved for single drug treatment, and 12 as fixed dose combination by the U.S. Food and Drug Administration (US-FDA) [7,77,78,84-91]. They are divided into six classes according to their mechanism of action. 

A variable-dose plasma concentration-controlled approach to combination antiretroviral therapy (zidovudine, lamivudine, and indinavir) has been compared with conventional fixed-dose therapy in 40 patients in a randomized, 52-week, open trial (6). Significantly more concentration-controlled recipients achieved the desired concentrations for aU three drugs there was a good response in 15 of 16 concentration-controlled recipients compared with nine of 17 conventional regimen recipients. However, there was no difference in the occurrence... 

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