Fish complement system

The complement system of bony fish and cartilaginous fish appears to be fully equipped with the three C3-activation pathways and the cytolytic... 

BOSHRA H, LI J, SUNYER JO (2006), Recent advances on the complement system of teleost fish , Fish Shellfish Immunol, 20, 239-62. 

NAKAO M, TSUJiKURA M, icfflKi s, VO TK, SOMAMOTO T (2011), The Complement system in teleost fish progress of post-homolog-hunting researches , Dev Comp Immunol, in press. 

The experiments described above indicate that technology is available to couple SPR with mass spectrometry. These methods should be useful for protein-protein interaction mapping. For example, immobilized proteins can be used as hooks for fishing binding partners from complex protein mixtures under native conditions. The coupling of techniques can lead not only to the rapid identification of interacting proteins but will also provide information on the kinetic parameters of the interaction. This approach should serve as an excellent complement to the use of in vivo techniques such as the yeast two-hybrid system. 

Considerable interest has developed concerning the nature of the mixed function oxidase system in fish and the role that this system may play in the development of toxic responses in these animals. Studies have shown that components of the mixed function oxidase system are present in relatively high concentrations in fish liver (4, 5, 6) and that the enzyme systems in this organ are capable of many of the biotransformation reactions already described for the mammalian liver (7, 8, 9). The presence of this complement of enzymes in the livers of many fishes suggests that this organ too may be particularly sensitive to insult from sub lethal concentrations of many waterborne toxicants. For this reason, methods to evaluate liver function in fish may be particularly useful in identifying the sublethal effects of certain classes of toxicants. 

Crustaceans and fishes both live in aquatic environments, but they are phylo-genetically distant and the morphology and mechanisms of their chemosensory systems are quite different. Experimental approaches using members of these two taxa can therefore complement and stimulate each other. This review provides... 

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