Process optimization, film coating

Number of spray guns to be used In any film-coating process, it is critical to ensure that the spray zone is optimized with respect to these key criteria ... 

Table 8 Ranges of Process Variables Used During Optimization of the Enteric Film-Coating Process...

Cunningham CR. Spray gun optimization for aqueous film-coating processes. Proceedings of TechSource Coating Technology 99, Atlantic City, NJ, Oct 12-13, 1999. 

Scale-up of a film-coating process is dependent on the functionality of coating. A non-functional coating used to mask color change and taste, or used for identification, is considered a non-critical step, and optimization is made to maximize coating time. The assumption is made that standard coating formulations are used... 

Andersson M, Folestad S, Gottfires J, Johansson MO, Josefson M, Wahlund KG. Quantitative analysis of film coating in a fluidized-bed process by in-line NIR spectroscopy and multivariate batch calibration. Anal Chem 2000 72 2099-2108. Vazquz Elizabeth Rivera Master of Science Thesis, Optimization of Drying-end-points. Measurements for the automation of a fluidized-bed dryer using FT-NIR Spectroscopy, Univ of Puerto Rico, 2004. 

Table 13 Process Variables Used in the Development and Optimization of a Coating Process Designed for the Application of a Modified-Release Film Coating to Drug-Loaded Pellets...

Every coating process is different and requires optimization. Unfortunately, most coating processes are validated with a minimal number of batches. Modeling the coating process allows the formulator to set the quality of the inlet air to maintain an elegant and functional film coating. 

First layers of a 10-pm thin monolithic sihca gel structure with 1- to 2- am macropores and 3- to 4-nm mesopores were manufactured by hydrolytic polycondensation of hquid alkoxysiloxane films coated on glass substrates. Separations were performed for steroids, pesticides, dyestuffs, amino acids, pharmaceutically active ingredients, phenols, and plasticizers [3,4]. Besides this commercially available monohthic UTLC product, which resulted from these studies and was used for several hyphenations to MS [5-10], the sol-gel synthesis process was further improved to provide a high homogeneity, reproducibihty, and mechanical stability of the layer material. Optimized synthesis is still used to build up monolithic stationary phases with new characteristics, and synthetic dyes and food dyes were separated on a 100-pm thin layer [11,12]. 

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