Fibrosis murine models

Murine models have been instrumental in representing human disease in vivo. Transgenic approaches have produced mice with genetic defects that promote susceptibility to fibrosis, including abnormal expression of chemokines and/or chemokine receptors. These models have elucidated the factors that are conducive to fibrosis and have thus revealed the central roles of certain chemokines and chemokine receptors. Conventional methods of inducing... 

Treatment with antibodies to CCRl led to a reduction in both inflammatory cell inflltrates and the development of flbrosis (80). Similar effects have been seen in murine model of obliterative bronchiolitis where the flbrotic response associated with this disorder was attenuated in CCR2 mice (65). This suggests that targeting chemokine receptors may be an efficient way to inhibit pulmonary fibrosis. 

Ryman-Rasmussen, J.P., Tewksbury, E.W., Moss, O.R., Cesta, M.F., Wong, B.A., and Bonner, J.C. (2008) Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in a murine model of allergic asthma. Am. J. Respir. Cell Mol. Biol., 40, 349-358. 

Hu, C., Wang, Y., Fan, Y, Li, H., Wang, C., Zhang, J., Zhang, S., Han, X., Wen, C. (2015) Lipidomics revealed idiopathic pulmonary fibrosis-induced hepatic lipid disorders corrected with treatment of baicalin in a murine model. AAPS J. 17,711-722. 

Miyazaki Y, Araki K, Vesin C, Garcia 1, Kapanci Y, Whitsett JA, Piguet P-F, Vassalli P. Expression of a tumor necrosis fector-a transgene in murine lung causes lymphocytic andfibrosingalveohtis. A mouse model of progressive pulmonary fibrosis. J Clin Invest 1995 96 250-259. 

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