Fibrinogen molecular weight

Thrombin, the two-chain derivative of the prothrombin molecule, has a molecular weight of approximately 37,000 daltons. Its proteolytic properties induce the conversion of fibrinogen to fibrin to produce the initial visible manifestation of coagulation, the soluble fibrin clot. In addition, thrombin influences the activity of Factors V, VIII, and XIII and plasmin. Thrombin affects platelet function by inducing viscous metamorphosis and the release reaction with subsequent aggregation. 

Factor II. Prothrombin is a vitamin K-dependent compound synthesized by the Hver. When prothrombin is activated it is cleaved at two sites, resulting in a two-chain molecule linked by a disulfide bond that has a molecular weight of 37,000 daltons. Thrombin is the serine protease that initiates the conversion of soluble fibrinogen into fibrin. 

Schmaier AH. Silver L. Adams AL, Fischer GC, Munoz PC, Vroman L, et al The effect of high molecular weight kininogen on surface-adsorbed fibrinogen. Thromb Res 1984 33 51-67. 

Heparin may be given intravenously or subcutaneously, and there is no universally accepted dose. Full-dose heparin therapy in adults is a bolus of 5000 units, followed by a continuous infusion of 1000 units/hour. Since the aPTT is already elevated in individuals with DIC, monitoring full-dose heparin therapy may be difficult, and D-dimer and fibrinogen levels maybe better markers of activity. Subcutaneous heparin at a dose of 80 to 100 units/kg every 4 to 6 hours and low-molecular-weight heparins are other, less studied options.25... 

Fibrinogen. Serum protein, together with the mechanism of hemo-coagulation, is present in normal CSF only in trace concentrations, probably due to its high molecular weight. An increase in CSF concentrations is always connected with severe damage of the blood-CSF barrier or mechanical obstruction in the... 

Marder, V. J., Shulman, N. R., and Carroll, W. R. (1969). High molecular weight derivatives of human fibrinogen produced by plasmin. J. Biol. Chem. 244, 2111-2119. 

Factor deficiencies include disorders of fibrinogen such as afibrinogenemia and dysfibrinogenemias, prothrombin deficiency, factor V VII, X, XI, XII, and XIII deficiency, prekallikrein and high-molecular-weight kininogen deficiency, combined factor deficiencies, a2 anti-plasmin deficiency, a] antitrypsin Pittsburgh, and protein Z deficiency. 

---