Fibrinogen-fibrin degradation products

Fig. 9. Steps in the formation of fibrinogen-fibrin degradation products. The approximate molecular masses of fibrinogen degradation products in kilodaltons (KDa) are indicated.

Fibrinolytics. Figure 2 Various fibrin structures for plasmin. Fibrinogen (Fg) is converted to fibrin (F) by thrombin (T), and thrombin can also convert factor XIII (XIII) to activated factor XIII (Xllla). The latter produces crosslinks between fibrins (FxxF) and also may crosslink fibrin with a2-plasmin inhibitor (FxxFxxPI). The efficiency of digestion of these plasmin substrates by plasmin, resulting in the soluble fibrin degradation products (FDP), is different. The amount of FDP formed in time is expressed in arbitrary units. 

A number of laboratory tests are available to measure the phases of hemostasis described above. The tests include platelet count, bleeding time, activated partial thromboplastin time (aPTT or PTT), prothrombin time (PT), thrombin time (TT), concentration of fibrinogen, fibrin clot stabifity, and measurement of fibrin degradation products. The platelet count quantitates the number of platelets, and the bleeding time is an overall test of platelet function. aPTT is a measure of the intrinsic pathway and PT of the extrinsic pathway. PT is used to measure the effectiveness of oral anticoagulants such as warfarin, and aPTT is used to monitor heparin therapy. The reader is referred to a textbook of hematology for a discussion of these tests. 

Widespread hemorrhagic brain infarcts and intracranial hemorrhages tend to cause an acute or subacute global encephalopathy rather than stroke-like episodes. The diagnosis is confirmed by a low platelet count, low plasma fibrinogen, and raised fibrin degradation products and D-dimer. 

It is known that endotoxin causes the reduction of blood platelet numbers and fibrinogen content, the increase of fibrin degradation product (FDP) and the prolongation of prothrombin time. The oral administration of baicalein (50 mg/kg) and baicalin (50 mg/kg) prevented the reduction of blood platelet number and fibrinogen content in rats with endotoxin-induced disseminated intravascular coagulation (DIC) "Table (16)". [31]... 

Fetal scalp blood pH Fibrin degradation products Fibrinogen Folic acid... 

Smith, E.B., Fibrinogen, fibrin and fibrin degradation products in relation to atherosclerosis. Clin. Haematol., 1986, 15(2) 355-370. 

The actions of plasmin on both fibrin and fibrinogen have been studied extensively. Plasmin cleaves fibrin and fibrinogen into a family of fragments known as fibrinogen and fibrin (FDP-fdp) degradation products. 

Degradation / Thrombin y Fibrin split products Fibrinogen------->- Fibrin — products... 

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